Toll like receptor 1 genetic polymorphisms among helicobacter pylori positive and negative Thai patients; a summary report

Beuy Joob1*, Viroj Wiwanitkit2

Abstract


Toll like receptor (TLR) 1 is an important biomolecule that has plays a pivotal role in several
medical disorders. In Helicobacter pylori related gastritis, TLR is observed on its clinical
interrelationship with gastric dysplasia that is a precancerous condition. Here, the authors
summative analyzed the observation of TLR1 polymorphism among Thai patients with H. pylori
positive and negative status. According to the analysis, the CC polymorphism is common among
the cases with positive H. pylori patients and CT polymorphism is common among negative
H. pylori patients. From statistical analysis, no significant relationship between positivity for
H. pylori and TLR1 polymorphism was detected (P > 0.05). Based on this observation, TLR1
polymorphism test might not be helpful in monitoring patients with H. pylori infection.

Keywords:
Toll like receptor 1, Helicobacter
pylori, Genetic, Polymorphism

Citation: Joob B, Wiwanitkit V. Toll like receptor 1 genetic polymorphisms among helicobacter pylori positive and
negative Thai patients; a summary report. Acta Persica Pathophysiol. 2018;3:e02.


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