Enzymatic and nonenzymatic antioxidants in kidney diseases

Amin Hasanvand, Saeideh Darabi

Abstract


Reactive species and oxidative stress have become increasingly known during the last decade as signifcant factors that infuence different cellular functions of the body. Normally, reactive species (reactive oxygen
species and reactive nitrogen species) are produced by natural cellular reactions. The suffcient level of reactive species is vital for cellular pathway like signaling, cellular proliferation and also cellular growth. Although the high concentrations of oxidants are produced by an imbalance between oxidant and antioxidant defense system, they have pathogenetic effects on living organisms and also cause tissue damage. This phenomenon is called oxidative stress. Oxidative stress contributes to several pathological
situations, including hypertension, diabetes, cancer, chronic diseases like chronic kidney disease and some acute health problems. In this paper, we summarized the formation of main oxidants originating from a variety of important sources, consisting of cellular metabolism and ecological factors and also enzymatic and nonenzymatic antioxidant systems that have a major role in the regulation of reducing and oxidizing state in the body.

 

 

Citation: Hasanvand A, Darabi S. Enzymatic and nonenzymatic antioxidants in kidney diseases. Ann Res Antioxid. 2018;3(1):e01


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