Ameliorative effect of royal jelly against nephrotoxicity induced by gentamicin

Mahmoud Rafieian-Kopaei, Samira Asgharzadeh, Mohammad Reza Tamadon, Banafsheh Yalameha

Abstract


Introduction:  Royal jelly is a natural product that has antioxidant properties and has protective effects against gentamicin-induced renal toxicity.
Objectives: In this study, antioxidant effect of royal jelly were investigated against gentamicin-induced nephrotoxicity.
Materials and Methods: Fifty adult male Wistar rats were randomly divided into fve group 1) Animals received gentamicin (GM) (80 mg/kg, i.p.) for 7 days and saline for 10 days, group 2) Received 100 mg/kg body weight/d royal jelly for 10 days, group 3) Received 100 mg/kg body weight/d royal jelly for 3 days and then royal jelly plus GM (80 mg/kg; ip) for 7 more days, group 4) Received GM for 7 days and then royal jelly for 10 days, group 5) Received saline for 10 days. Histological changes were evaluated for severity of renal injury (epithelial cell degeneration, vacuolization, tubular dilatation, tubular cell fattening, and hyaline cast and also debris materials in tubular lumen on a semi-quantitative score from 1 to 5, while the score of zero was designated to the normal tissue without damage.
Results:  Gentamicin signifcantly increased mean of delitation, degeneration, vacuolization and score level (P  <  0.05). Royal jelly has a protective effect against gentamicin-induced kidney injury by (P  <  0.05).
Conclusion: In vivo result showed that royal jelly is a potential protector against gentamicin- induced oxidative stress and histological.

 

Citation: Rafieian-Kopaei M, Asgharzadeh S, Tamadon MR, Yalameha B.
Ameliorative effect of royal jelly against nephrotoxicity induced by gentamicin. Ann Res Antioxid. 2018;3(1):e05.


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