Cisplatin; nephrotoxicity and beyond

Azar Baradaran, Majid Tavafi, Mohammad-Reza Ardalan, Mahmoud Rafieian-Kopaei

Abstract


Abstract

Cisplatin is one of the most extensively administered and highly effective substances for the treatment of several solid tumors; however, it shows dose-dependent renal side effects. This review was aimed to summaries and present the recently published papers on the toxicities of cisplatin, focussing on its nephrotoxicity. Directory of Open Access Journals (DOAJ), Google
Scholar, PubMed, EBSCO, and Web of Science have been searched. Renal toxicity is clinically the most important and well-known side effect of cisplatin. Various investigations suggested that several mechanisms including oxidative stress, DNA injury, and inflammatory responses, are involved in cisplatin-induced renal toxicity. In recent years, much interest has been directed towards a gender difference in renal toxicity of cisplatin. The literature on gender-related cisplatin toxicity shows conflicting results even on the same tissues. Cisplatin induced renal toxicity maybe sex related probably due to differences in kidney circulation. Because of ill-understood mechanisms, it requires further investigations.

 

Core tip


Several mechanisms such as oxidative stress, DNA injury, and inflammatory responses are involved in cisplatin-induced renal toxicity. In recent years, much interest has been directed towards a gender difference in cisplatin induced renal toxicity. The literature on gender-related cisplatin toxicity shows conflicting results even on the same tissues. Cisplatin induced renal toxicity maybe sex-related even though the underlying mechanisms are ill-understood. Gender differences in kidney circulation may be an important factor contributing to this difference; however, understanding the underlying mechanism requires further investigations.

 

Citation

Baradaran A, Tavafi M, Ardalan MR Rafieian-Kopaei M. Cisplatin; nephrotoxicity and beyond. Ann Res Antioxid. 2016; 1(2):e014.


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