A nephrology viewpoint on renoprotective properties of metformin

Ramin Tolouian, Hamid Nasri, Azar Baradaran, Parto Nasri, Samaneh Khodadadi, Mahmoud Rafieian-Kopaei

Abstract


Abstract

Globally diabetes is a major cause of kidney failure. Metformin is non-nephrotoxic and one of the first choice hypoglycemic agents in treatment of diabetes. We reviewed the effect of metformin in diabetic kidney disease (DKD). Directory of open access journals (DOAJ), Google Scholar, PubMed, EBSCO, and Web of Science with keywords relevant to; chronic kidney disease, diabetes mellitus, metformin, diabetic nephropathy, have been searched. Diabetes causes expression of extracellular matrix mediators and secretory factors that eventually lead to morphological changes in mesangial, interestitium and glomerular cells. The biguanide, metformin is derived from French lilac (Galega officinalis). Metformin is a commonly prescribed drug for type II diabetes around the world due to its safety record and reduction of micro-vascular and cardiovascular events. It appears that metformin has multiple roles in protecting kidney in diabetic patients by tubular cell protection, improving hypertension, albuminuria and restoring the glomerular podocytes. It may be justified to use metformin for nephron-protection in early stage of DKD.

 

Core tip

Diabetic kidney disease is becoming a major public health problem due to
high morbidity, mortality and cost. It has been shown that metformin reduces macrovascular complications and mortality in individuals with type 2 diabetes mellitus. It may be justified to use metformin for nephron-protection in patients with early stage of diabetic kidney disease (DKD). Further clinical investigation on this subject is needed.

 

Citation

Tolouian R, Nasri H, Baradaran A,Nasri P, Khodadadi S, Rafieian-Kopaei M.A nephrology viewpoint on renoprotective properties of metformin. Ann Res Antioxid. 2016;1(2):e20.


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