Anti-tuberculosis drug resistance and mutation in efflux pump Rv1258c (Tap); explanation based on molecular weight change

Won Sriwijitalai, Viroj Wiwanitkit

Abstract


The basic management of tuberculosis is the use of anti-tuberculosis drug. The drug resistance becomes an emerging important public health problem worldwide. The resistance of anti-tuberculosis drug is considered a big obstacle for success in tuberculosis control. The molecular mechanism underlying anti-tuberculosis drug resistance is widely studied. Of several underlying genetic backgrounds, the mutation in efflux pump Rv1258c (Tap) is an important genetic factor mentioned for the relationship to
the anti-tuberculosis drug resistance. In this article, the authors use the standard quantum calculation analysis to assess the molecular change in important mutations of efflux pump Rv1258c (Tap), V219A and S292L. Based on the analysis, it can explain the observed effect of mutants on the anti-tuberculosis drug resistance.

Keywords:Anti-tuberculosis, Drug resistance,
Efflux pump, Mycobacterium tuberculosis, Anti-tuberculosis therapy

Citation:Sriwijitalai W, Wiwanitkit V. Anti-tuberculosis drug resistance and mutation in efflux pump Rv1258c (Tap); explanation based on molecular weight change. Geriatr Persia. 2018;2:e03.


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